Endocrine Abstracts

Introduction: Chronic exposure to glucocorticoid excess, either endogenous or exogenous, is associated with a hypercoagulable state and a high thromboembolism risk. The underlying mechanism of this phenomenon is still unclear. Clinical studies have indicated various abnormalities of procoagulant, anti-coagulant and fibrynolytic factors, e.g.: alterations of clotting factors (F), plasminogen activator inhibitor (PAI-1), plasminogen, antithrombin. Moreover, other consequences of...